The incidence and geographical distribution of dengue have greatly increased in recent years dengue is an acute mosquito-transmitted viral disease characterised by fever, headache, muscle and joint pains, rash, nausea, and vomiting. Dengue (pronounced dengee) fever is a painful, debilitating mosquito-borne disease caused by any one of four closely related dengue viruses these viruses are related to the viruses that cause west nile infection andyellow feveran estimated 390 dengue infections occur worldwide each year, with about 96 million resulting in illness. The pathogenesis of dengue haemorrhagic fever and dengue shock syndrome is complex process mediated by the combined complex of virus and antibody interaction called antibody dependent enhancement, and the aberrant immense response of immune system to the dengue infection. Dengue fever (df) and dengue haemorrhagic fever (dhf) are suitable models for immunogenetic studies, yet only superficial efforts have been made to study dengue disease to date df and dhf can be caused by both primary and secondary infection by any of the four serotypes of the dengue virus.
Review article dengue fever and dengue haemorrhagic fever: challenges of controlling an enemy still at large. Plasma leakage and intrinsic coagulopathy are the pathological hall marks in dengue haemorrhagic fever (dhf) viral virulence, infection enhancing antibodies, cytokines and chemical mediators in the setting of intense immune activation are the key players implicated in the pathogenesis of dhf the exact nature of which is yet to be fully understood. Full-text paper (pdf): pathogenesis of dengue haemorrhagic fever and its impact on case management.
Dengue haemorrhagic fever / dhf dhf is a severe and potentially fatal form of acute febrile illness characterised by cutaneous and intestinal haemorrhages due to thrombocytopenia, haemoconcentration, hypovolaemic shock and neurologic disturbances. The pathogenesis of dengue (dc-sign-336) was associated with protection against dengue fever, but not dengue haemorrhagic fever this finding suggests that . Pathophysiology of dengue hemorrhagic fever by jessica pestka, ehow contributor updated: february 3, 2011 signs of dengue fever dengue fever, a contagious disease transmitted by the aedes aegypti mosquito, infects between 50 million and 100 million people worldwide each year. This paper reviews the changing epidemiology of dengue and dengue hemorrhagic fever by geographic region, the natural history and transmission cycles, clinical diagnosis of both dengue fever and dengue hemorrhagic fever, serologic and virologic laboratory diagnoses, pathogenesis, surveillance, prevention, and control. Dengue hemorrhagic fever is the most severe manifestation of human infection by the mosquito-borne flavivirus dengue dengue virus is an enveloped virus, with a.
Dengue dengue hemorrhagic hemorrhagic fever fever pathogenesis and pathophysiology alan alan r r tumbelaka tumbelaka,, dr dr spa(k spa(k)) dengue virus • family flaviviridae • genus flavivirus • enveloped , single strand rna viruses • genomic rna 11 kb and encodes – 3 structural . Approximately 90% of cases of dengue haemorrhagic fever (dhf) are in children under 5 years of age  world health organization, regional office for south-east asia. During dengue virus infection a unique cytokine, cytotoxic factor (hcf), is produced that is pathogenesis-related and plays a key role in the development of dengue haemorrhagic fever (dhf).
Symptomatic dengue includes, classical dengue fever, dengue haemorrhagic fever (dhf) and dengue shock syndrome (dss) i classical dengue fever: it is characterized by fever, rashes, severe headache, pain behind eyes, pain in muscle and joints, enlarged lymph nodes,. Dengue fever becomes more virulent during a second infection by a viral hemorrhagic fever is a possible cause of the plague of viral haemorrhagic fever. Dengue haemorrhagic fever in adults: a prospective study of 110 cases the first major outbreak of dengue hemorrhagic fever in delhi, india the 2003 outbreak of dengue fever in delhi, india.
Dengue and dengue hemorrhagic fever or reflections on the pathogenesis of dengue hemorrhagic fever am j trop med hyg 197726:337-43. Continued geographic expansion of dengue viruses and their mosquito vectors has seen the magnitude and frequency of epidemic dengue/dengue hemorrhagic fever (df/dhf) increase dramatically. Immunological enhancement and the pathogenesis of dengue haemorrhagic fever - volume 89 issue 3 - j s porterfield.